Antonella Naldini
C.V.

  1. Naldini A, Pucci A and Carraro F. Hypoxia induces the expression and release of interleukin 1 receptor antagonist in mitogen-activated mononuclear cells. Cytokine 13: 334-341, 2001.
  2. Naldini A, Pucci A, Carney DH, Fanetti G and Carraro F. Thrombin enhancement of interleukin-1 expression in mononuclear cells: involvement of proteinase-activated receptor-1. Cytokine 20: 191-199, 2002.
  3. Naldini A, Carney DH, Pucci A and Carraro F. Human alpha-thrombin stimulates proliferation of interferon-gamma differentiated, growth-arrested U937 cells, overcoming differentiation-related changes in expression of p21CIP1/WAF1 and cyclin D1. J Cell Physiol 191: 290-297, 2002.
  4. Naldini A, Carney DH, Pucci A, Pasquali A and Carraro F. Thrombin regulates the expression of proangiogenic cytokines via proteolytic activation of protease-activated receptor-1. Gen Pharmacol 35: 255-259, 2002.
  5. Naldini A, Pucci A, Bernini C and Carraro F. Regulation of angiogenesis by Th1- and Th2-type cytokines. Curr Pharm Des 9: 511-519, 2003.
  6. Naldini A, Aarden L, Pucci A, Bernini C and Carraro F. Inhibition of interleukin-12 expression by alpha-thrombin in human peripheral blood mononuclear cells: a potential mechanism for modulating Th1/Th2 responses. Br J Pharmacol 140: 980-986, 2003.
  7. Leali D, Dell'Era P, Stabile H, Sennino B, Chambers AF, Naldini A, Sozzani S, Nico B, Ribatti D and Presta M. Osteopontin (Eta-1) and fibroblast growth factor-2 cross-talk in angiogenesis. J Immunol 171: 1085-1093, 2003.
  8. Pacini S, Pellegrini M, Migliaccio E, Patrussi L, Ulivieri C, Ventura A, Carraro F, Naldini A, Lanfrancone L, Pelicci P and Baldari CT. p66SHC Promotes Apoptosis and Antagonizes Mitogenic Signaling in T Cells. Mol Cell Biol 24: 1747-1757, 2004.
  9. Carraro F, Pucci A, Naldini A, Schenone S, Bruno O, Ranise A, Bondavalli F, Brullo C, Fossa P, Menozzi G, Mosti L, Manetti F, Botta M. Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells. J Med Chem 47(7):1595-1598, 2004.
  10. Schenone S, Bruno O, Ranise A, Bondavalli F, Brullo C, Fossa  P, Mosti L, Menozzi G, Carraro F, Naldini A, Bernini  C, Manetti  F, Botta M. New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation. Bioorg Med Chem Lett 14: 2511-2517, 2004.
  11. Naldini A, Carraro F, Baldari CT, Paccani SR, Bernini C, Keherly MJ, Carney DH. The thrombin peptide, TP508, enhances cytokine release and activates signaling events. Peptides. 25(11):1917-1926, 2004.
  12. Cavarra E, Carraro F, Fineschi S, Naldini A, Bartalesi B, Pucci A, Lungarella G. Early response to bleomycin is characterized by different cytokine and cytokine receptor profiles in lungs. Am J Physiol Lung Cell Mol Physiol. 287(6):L1186-1192, 2004.
  13. Naldini A, Carraro F. Role of inflammatory mediators in angiogenesis. Curr Drug Targets Inflamm Allergy. 4(1):3-8, 2005.
  14. Massi D, Naldini A, Ardinghi C, Carraro F, Franchi A, Paglierani M, Tarantini F, Ketabchi S, Cirino G, Hollenberg MD, Geppetti P, Santucci M. Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma. Hum Pathol. 36: 676 - 685, 2005.
  15. Naldini A, Bernini C, Pucci A, Carraro F. Thrombin-mediated IL-10 upregulation involves protease-activated receptor (PAR)-1 expression in human mononuclear leukocytes. J Leukocyte Biol.  78: 736 - 744, 2005.
  16.  Naldini A,  Morena E, Filippi I, Pucci A, Bucci M, Cirino G,  Carraro F. Thrombin inhibits interferon-gamma production in human peripheral blood mononuclear cells by promoting a Th-2 profile.  J Interferon Cytokine Research. 26: 793 – 799, 2006.
  17. Carraro F, Naldini A, Pucci A, Locatelli GA, Maga G, Schenone S, Bruno O, Ranise A, Bondavalli F, Brullo C, Fossa P, Menozzi G, Mosti L, Modugno M, Tintori C, Manetti F, Botta M. Pyrazolo[3,4-d]pyrimidines as Potent Antiproliferative and Proapoptotic Agents toward A431 and 8701-BC Cells in Culture via Inhibition of c-Src Phosphorylation. J Med Chem. 49: 1549 – 1561, 2006.
  18. Franchi A, Massi D, Santucci M, Masini E, Degl'Innocenti DR, Magnelli L, Fanti E, Naldini A, Ardinghi C, Carraro F, Gallo O. Inducible nitric oxide synthase activity correlates with lymphangiogenesis and vascular endothelial growth factor-C expression in head and neck squamous cell carcinoma. J Pathol. 208: 439 – 445, 2006.
  19. Naldini A, Leali D, Pucci A, Morena E, Carraro F, Nico B, Ribatti D, Presta M. IL-1 Mediates the Proangiogenic Activity of Osteopontin-Activated Human Monocytes. J Immunol. 17: 4267 – 4270, 2006.
  20. Carraro F, Pucci A, Pellegrini M, Pelicci PG, Baldari CT, Naldini A. p66Shc is involved in promoting HIF-1alpha accumulation and cell death in hypoxic T cells. J Cell Physiol. 211:  439 – 447, 2007.
  21. Manetti F, Pucci A, Magnani M, Locatelli GA, Brullo C, Naldini A, Schenone S, Maga G, Carraro F, Botta M. Inhibition of Bcr-Abl Phosphorylation and Induction of Apoptosis by Pyrazolo[3,4-d]pyrimidines in Human Leukemia Cells. ChemMedChem.2: 343 – 353, 2007.
  22. Di Serio C, Pellerito S, Duarte M, Massi D, Naldini A, Cirino G, Prudovsky I, Santucci M, Geppetti P, Marchionni N, Masotti G, Tarantini F. Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism. Basic Clin Pharmacol Toxicol. 101(1): 63-9, 2007.
  23. Materazzi S, Pellerito S, Di Serio C, Paglierani M, Naldini A, Ardinghi C, Carraro F, Geppetti P, Cirino G, Santucci M, Tarantini F, Massi D.  Analysis of protease-activated receptor-1 and -2 in human scar formation. J Pathol. 212: 440 – 449, 2007.
  24. Naldini A, Ardinghi C, Massi D, Santucci M, Franchi A, Tarantini F, Geppetti P, Cirino G, Carraro F. A Ribonuclease Protection Assay-Based Approach for Analysis of Angiogenic Gene Expression in Archival Tissues. Diagn Mol Pathol. 16(3): 147-52, 2007.
  25. Boraldi F, Annovi G, Carraro F, Naldini A, Tiozzo R, Sommer P, Quaglino D. Hypoxia influences the cellular cross-talk of human dermal fibroblasts. A proteomic approach. Biochim Biophys Acta. 1774: 1402 – 1413, 2007.
  26. Manetti F, Brullo C, Magnani M, Mosci F, Chelli B, Crespan E, Schenone S, Naldini A, Bruno O, Trincavelli ML, Maga G, Carraro F, Martini C, Bondavalli F, Botta M. Structure-Based Optimization of Pyrazolo[3,4-d]pyrimidines as Abl Inhibitors and Antiproliferative Agents toward Human Leukemia Cell Lines. J Med Chem. 51: 1252 – 1259, 2008.
  27. Naldini A, Morena E, Fimiani M, Campoccia G, Fossombroni V, Carraro F. The Effects of Autologous Platelet Gel on Inflammatory Cytokine Response in Human Peripheral Blood Mononuclear Cells. Platelets. 19: 268 – 274, 2008.
  28. Falchi F, Manetti F, Carraro F, Naldini A, Maga G, Crespan E, Schenone S, Bruno O, Brullo C, Botta M. 3D QSAR Models Built on Structure-Based Alignments of Abl Tyrosine Kinase Inhibitors. Chemmedchem.4: 976 – 987, 2009.
  29. Moretti S, Nassini R, Prignano F, Pacini A, Materazzi S, Naldini A, Simoni A, Baroni G, Pellerito S, Filippi I, Lotti T, Geppetti P, Massi D. Protease-activated receptor-2 downregulation is associated to vitiligo lesions.  Pigment Cell Melanoma Res. 22: 335 – 338, 2009.
  30. Naldini A, Filippi I, Ardinghi C, Silini A, Giavazzi R, CARRARO F. Identification of a functional role for the protease-activated receptor-1 in hypoxic breast cancer cells.  Eur J Cancer. 45: 454 – 460, 2009.
  31. Leali D, Naldini A. The Role of Osteopontin in Angiogenesis.   Recent Advances in Angiogenesis and Antiangiogenesis, Bentham Science Publishers Ltd, eBook. 10 – 19, 2009.
  32. Silini A, Ghilardi C, Ardinghi C, Bernasconi S, Oliva P, Carraro F, Naldini A, Bani M, Giavazzi R. Protease-activated receptor-1 (PAR-1) promotes the mobility of human melanomas and is associated to their metastatic phenotype. Clin Exp Metastasis. 27: 43 – 53, 2010.
  33. Naldini A, Morena E, Pucci A, Pellegrini M, Baldari CT, Pelicci PG, Presta M, Ribatti D, Carraro F. The adaptor protein p66Shc is a positive regulator in the angiogenic response induced by hypoxic T cells. J Leukoc Biol.87: 365 – 369, 2010.
  34. Naldini A, Filippi I, Miglietta D, Moschetta M, Giavazzi R, Carraro F. Interleukin-1beta regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1alpha.  Eur J Cancer.  46: 3400  – 3408, 2010.
  35. Dreassi E, Zizzari A, Mori M, Filippi I, Belfiore A, Carraro F, Naldini A,  Santucci A, Schenone S, Botta M. 2-Hydroxypropyl-beta-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors. Eur J Med Chem. 45: 5958  – 5964, 2010.