Pier Giovanni Gervasi
C.V.

S. Marini, E. Grasso, V. Longo, P. Puccini, B. Riccardi, and P. G. Gervasi: 4-biphenylaldehyde and 9-anthraldehyde: two fluorescent substrates for determining P450 enzyme activities in rat and human. Xenobiotica 33,1-11, (2003).

C.Chiappe, A. De Rubertis, G. Piegari. G. Amato and P.G. Gervasi: Stereochemical aspects in thè 4-vinylcyclohexene biotransformation with rat liver microsomes and purifìed cytochome P450s: diepoxide formation and hydrolysis: Chem. Res. Toxicol. 16,56-65, (2003).

E. Vaccaro, M. Giorgi, V. Longo, G. Mengozzi, and P.G. Gervasi: Inhibition of cytochrome P450 enzymes by enrofioxacin in thè sea bass (Dicentrarchm Labrax). Aquatic Toxicol. 62, 27-33, (2003).

S. Dragoni, L. Bellik, M. Frosini, G. Sgaragli, S. Marini. P.G. Gervasi and M. Valoti: 1- Deprenyl metabolism by thè cytochrome P450 system in monkey (cercopithecus aethiops ) liver microsomes. Xenobiotica 33,181-195, (2003).

S. Bortolato, A. Zanovello, M. Rugge, M. Erotto, S. Marini, P. G. Gervasi, and M. Manno: Trifluoroacetylated proteins in liver and plasma of guinea pigs treated with HCFC-123 and halotane. Toxicol. Lett. 144, 35-47 (2003).

L. Pucci, D. Lucchesi, V. Chirulli, G. Penno, I. Johansson, P.G. Gervasi, S. del Prato and V. Longo: Cytochrome P4502J2 polymorphism in healthy Caucasians and those with diabetes mellitus. American J. PharmacoGenomics 3,355-358, (2003).

V. Longo, S. Marini, A. Salvetti, S. Angelucci, S. Bucci and P.G. Gervasi: Effects of p- naphtoflavone, phenobarbital and dichobenil on drug-metabolizing system of liver and nasal mucosa of Italian water frogs. Aquatic Toxicol. (2004) 69, 259-270.

A. Nannelli, A. De Rubertis, V. Longo and P.G. Gervasi: Effects of dioxane on P450 enzymes in   liver, lung and nasal mucosa of rat. Archives Toxicol. ( 2004 ) 79, 74-82.

E. Grasso, V. Longo, F. Coceani and P.G. Gervasi: Cytochrome P450 expression and catalytic activity in coronary arteries and liver of cattle. Biochem. Biophys. Acta (2005),1722, 116-123.

V. Chirulli, V. Longo, S. Marini, A. Mazzaccaro, R. Fiorio, and P.G. Gervasi: CAR and PXR expression and inducibility of CYP2B and CYP3A activities in rat and rabbit lungs. Life Science (2005) 76, 2535-2546.

L. Pucci, V. Chirulli, S. Marini, D. Lucchesi, G. Penno, P.G. Gervasi, S. Del Prato V. Longo: Expression and activity of CYP 2E1 in circulating lymphocytes are not altered in diabetic individuals. Pharmacological Res. (2005) 51, 561-565.

E. Vaccaro, V. Meucci, L. Intorre, G. Soldani, D. Di Bello, P.G. Gervasi, C. Pretti, Effects of 17 B-estradiol, 4-nonylphenol and PCB 126 on trhe estrogenic activity of phase 1 and 2 biotransformation enzymes in male sea bass (Dicentrarchus labrax). Aquatic Toxicol. (2005) 75, 293-305.

F. Regoli M. Nigro, M. Benedetti, S. Sgorbi, C. Pretti, P.G. Gervasi, D. Fattorini, Interactions between metabolism of trace metals and xenobiotic agonists of aryl hydrocarbon receptor in the antartctic fish Trematomus Bernacchii: environmental perspectives. Environ. Toxicol. Chem. (2005) 24, 1475-1462.

L. Malvasi, A. Zaghini, P.G. Gervasi, E. Vaccaro V. Chirulli, Induction of cytochrome P450 1A by naphto-flavone within the pig liver and central nervous system,. Vet. Res. Commun.(2006) 30, 333-336.

S. Marini, A. Nannelli, D. Sodini, S. Dragoni, M. Valoti, V. Longo, P.G. Gervasi, Expression, microsomal and mitochondrial  activities of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits. Life Sciences (2007) 80, 910-917.

A. Nannelli, A. Messina, S. Marini, S. Trasciatti, V. Longo, P.G. Gervasi, Effects of the anticancer dehydrotarplatin on cytochrome P450 and antioxidant enzymes in male rat tissues. Arch. Toxicol. (2007) 81, 479-487.

E. Vaccaro, A. Salvetti, R. Del Carratore, S. Nencioni, V. Longo and P.G. Gervasi, Cloning, Tissue Expression and Inducibility of CYP 3A79 from Sea Bass (Dicentrarchus labrax). J. Biochem. Mol. Toxicol. (2007) 21, 32-40.

D. Di Bello,  E. Vaccaro,  V. Longo,  F. Regoli, M. Nigro, Benedetti M, Gervasi, P.G, and  C., Pretti, Presence and inducibility by beta-naphthoflavone of CYP1A1, CYP1B1 and phase II enzymes in Trematomus Bernacchii, an antarctic fish. Aquatic Toxicol. (2007), 84, 19-26.

V. Longo, V. Chirulli, P.G. Gervasi, S. Nencioni, M. Pellegrini. Lisosan G, a powder of grain, does not interfer with the drug metabolizing enzymes and has a protective role on carbon tetrachloride-induced hepatotoxicity. Biotechnnol. Lett. (2007), 29, 1155-1159.

V. Chirulli, L. Malvasi, A. Zaghini, R. Fiorio, V. Longo P.G. Gervasi. Inducibility of AhR-regulated CYP genes by beta-naphthoflavone in the liver, lung, and heart of the pig. Toxicology, (2007), 240, 25-37.

A. Nannelli, V. Chirulli, V. Longo,  P.G. Gervasi. Expression and Induction by rifampicin of   CAR- and PXR.regulated CYP2B and CYP3A in liver, kidney and airways of pig, Toxicology, 252, 105-112  (2008).

A. Messina, V. Chirulli, P.G. Gervasi, V. Longo. Purification, molecular cloning, etherologous    expression and characterization of pig CYP1A2. Xenobiotica, 38, 1453-1470 (2008).

Messina, A. Nannelli, R. Fiorio, V. Longo,  P.G. Gervasi. Expression and inducibility of    CYP2B22, 3A22, 3A29, 3A46 by rifampicin in the respiratory and olfactory mucosa of pig, Toxicology, 360, 47-52 (2009).

A. Nannelli, F. Rossignolo, R. Tolando, P. Rossato, V. Longo and PG, Gervasi. Effects of β-naphthoflavone on AhR regulated genes (CYP1A1, 1A2, 1B1, 2S1, Nrf2, and GST) and antioxidant enzymes in various brain regions of pig. Toxicology.  265: 69-79  (2009).

A. Nannelli, F. Rossignolo, R. Tolando, P. Rossato, M. Pellegatti, V. Longo and PG, Gervasi.    Expression and distribution of CYP3A genes, CYP2B22, and MDR, MRP1, MRP2, LRP efflux transporters in brain of control and rifapicin-treated pigs. Mol. Cell Biochem. 337: 133-143 (2010).

A. Messina,  S. Nencioni, PG.Gervasi, K.H. Gotlinger ML. Schwartzman and V. Longo. Molecular cloning and enzymatic characterization of sheep CYP2J. Xenobiotica 40: 109-118 (2010)..

E. Puccinelli, PG. Gervasi, M. La Marca, P. Beffy and V. Longo. Expression and inducibility by phenobarbital of CYP2C33, CYP2C42, CYP2C49, CYP2B22 and CYP3As in porcine liver, kidney, small intestine, and nasal tissues. Xenobiotica 40: 525-535 (2010).

Longo V. Gervasi PG. Lubrano V. Cisplatin induced toxicity in rat liver: the protective effect of Lisosan G. Food Chem. Toxicol. 49: 233-237 (2011).