Vincenzo
Sorrentino is Professor of Histology and Director of the Section
of Molecular Medicine of the Department of Neuroscience at the University
of Siena and of the Unit of Molecular Medicine of the University
Hospital of Siena (AOUS).
He obtained his M.D. degree in 1980 from the Faculty of Medicine,
Roma, Italy. He did postdoctoral studies from 1983 to 1985 at the
Laboratory of Cellular and Molecular Biology, Nat. Cancer Inst.,
NIH, Bethesda, MD and Frederick Cancer Research Facility, Frederick,
MD where he worked on the molecular biology of oncogenes. From 1985
to 1987 he spent a second training period at the Laboratory of Viral
Oncology, Memorial Sloan-Kettering Cancer Center, New York, N. Y.
where he worked on the role of oncogenes and growth factors in neoplastic
transformation. In 1988 he joined as a staff scientist the European
Molecular Biology Laboratory, Heidelberg, Germany. Since 1993 he
has been Head of the Unit of Intracellular Signalling at DIBIT,
HSR, Milano, and Professor of Histology at the Medical Faculty of
the University Siena, before moving completely his research activities
to Siena in 2002.
Selected Publications
1. PALITTI F., MATARESE G.P., DIANA G.,
SORRENTINO V. and ROSSI G.B. In vivo studies of increased incidence
of sister chromatid exchanges in target cells of replication-competent
Friend murine leukemia virus. 1982. Cancer Research, 42, 4753-4757.
2. CIOÉ L., MEO P., SORRENTINO V. and ROSSI
G.B. Modulation of hemoglobin synthesis in K562(S) cells treated
with interferons. 1983. Blood 61, 1146-1154.
3. PULCIANI A., SANTOS E., LONG L.K., SORRENTINO
V. and BARBACID M. Ras gene amplification and malignant transformation.
1985. Mol. Cell. Biol. 5, 2836-2841.
4. SORRENTINO V., DROZDOFF V., MCKINNEY M., ZEITZ
L. and FLEISSNER E. Potentiation of Growth Factors activity by exogenous
c-myc expression. 1986. Proc. Natl. Acad. Sci. U.S.A. 83, 8167-8171.
5. SORRENTINO V., DROZDOFF V., ZEITZ L. and FLEISSNER
E. Increased radiation-induced transformation in C3H/10T1/2 cells
after transfer of an exogenous c-myc gene. 1987. Proc. Natl. Acad.
Sci. U.S.A. 84, 4131-4134.
6. SORRENTINO V., MCKINNEY M., GIORGI M., GEREMIA
R. and FLEISSNER E. Expression of cellular protooncogenes in the
mouse male germ cell line: a distinctive 2.4-kilobase pim-1 transcript
is expressed in haploid postmeiotic cells. 1988. Proc. Natl. Acad.
Sci. USA 85, 2191-2198.
7. SORRENTINO V. and BANDYOPADHYAY S. TGFß
inhibits Go/S-phase transition in primary fibroblasts. Loss of response
to the antigrowth effect of TGFß is observed after immortalization.
1989. Oncogene 4, 569-574.
8. MORRONE G., CORTESE R. and SORRENTINO V. Post-transcriptional
control of negative acute phase genes by transforming growth factor
ß. 1989. EMBO J. 8, 3767-3771.
9. SORRENTINO V., PEPPERKOK R., DAVIS R. L., ANSORGE
W. and PHILIPSON L. Cell proliferation inhibited by MyoD1 independently
of myogenic differentiation. 1990. Nature, 345, 813-815.
10. CICCARELLI C., PHILPSON L. and SORRENTINO V.
Regulation of the expression of growth arrest specific genes in
mouse fibroblasts. 1990. Mol. Cell. Biol. 10, 1525-1529.
11. ROSSI P., MARZIALI G., ALBANESI C., CHARLESWORTH
A., GEREMIA R. and SORRENTINO V. A novel c-kit transcript, potentially
encoding a truncated receptor, originates within a kit gene intron
in mouse spermatids. 1992. Developmental Biology. 152, 203-207.
12. COCCIA E.M., CICALA C., CHARLESWORTH A., CICCARELLI
C., ROSSI G.B., PHILIPSON L. and SORRENTINO V. Regulation and expression
of a growth arrest-specific gene (gas 5) during growth, differentiation
and development. 1992. Mol. Cell. Biol. 12, 3514-3521.
13. GIANNINI G., CLEMENTI E., CECI R., MARZIALI
G. and SORRENTINO V. Expression of a ryanodine receptor-Ca2+ channel
that is regulated by TGFß. 1992. Science 257, 91-94.
14. SORRENTINO V. and VOLPE P. Ryanodine receptors:
how many, where and why? 1993. Trends in Pharmacol. Sciences.14,
98-103.
15. GIANNINI G., CONTI A., MAMMARELLA S., SCROBOGNA
M. and SORRENTINO V. The ryanodine receptor/Calcium channel genes
are widely and differentially expressed in murine brain and peripheral
tissues. 1995. Journal of Cell Biology 128, 893-904.
16. BERTOCCHINI F., OVITT C., CONTI A., BARONE
V., SCHOLER H.R., BOTTINELLI R., REGGIANI C. and SORRENTINO V. Requirement
for the ryanodine receptor type 3 for efficient contraction in neonatal
skeletal muscles. 1997. The EMBO Journal. 16, 6956-6963.
17. SONNLEITNER A., CONTI A., BERTOCCHINI F., SCHINDLER
H. and SORRENTINO V. Functional properties of the ryanodine receptor
type 3 (RyR3) Ca2+ release channel. 1998. The EMBO Journal. 17,
2790-2798.
18. SORRENTINO V. and REGGIANI C. Expression of
ryanodine receptor type 3 in skeletal muscle. A new partner in excitation-contraction
coupling? 1999. Trends in Cardiovascular Medicine 9, 54-61.
19. FLUCHER B.E., CONTI A., TAKESHIMA H. and SORRENTINO
V. Type 3 and Type 1 ryanodine receptors are colocalized in triads
of the same mammalian skeletal muscle fibers. 1999. J. Cell. Biology
146, 621-30.
20. BALSCHUN D., WOLFER D.P., BERTOCCHINI F., BARONE
V., CONTI A., ZUSCHRATTER W., MISSIAEN L., LIPP H.P., FREY U. and
SORRENTINO V. Deletion of the ryanodine receptor Type 3 (RyR3) impairs
forms of synaptic plasticity and spatial learning. 1999. EMBO J.
18, 5264-5273.
21. PRIORI S.G., NAPOLITANO C., TISO N., MEMMI
M., VIGNATI G., BLOISE R., SORRENTINO V. and DANIELI G.A. Mutations
in the cardiac Ryanodine Receptor gene (hRyR2) underlie Catecholaminergic
Polymorphic Ventricular Tachycardia. 2001. Circulation 103, 196-200.
22. SORRENTINO V. and R. RIZZUTO. Molecular genetics
of Ca2+ stores and intracellular Ca2+ signalling. 2001. Trends in
Pharmacol. Sciences. 22, 459-464.
23. SIMEONI I., ROSSI D., ZHU X., GARCÍA
J., VALDIVIA H.H. and SORRENTINO V. Imperatoxin A (IpTx(a)) from
Pandinus imperator stimulates [(3)H]ryanodine binding to RyR3 channels.
2001. FEBS Letters 508, 5-10.
24. ROSSI D., SIMEONI I., MICHELI M., BOOTMAN M.,
LIPP P., ALLEN P.D. and SORRENTINO V. RyR1 and RyR3 Isoforms provide
distintct intracellular Ca2+ signals in HEK 293 cells. 2002. J Cell
Sci. 115, 2497-2504
25. SALANOVA M., PRIORI G., BARONE V., INTRAVAIA
E., FLUCHER B., CIRUELA F., MCILHINNEY R.A.J., PARYS J.B., MIKOSHIBA
K. AND SORRENTINO V. Homer proteins and InsP3 receptors co-localize
in the longitudinal sarcoplasmic reticulum of skeletal muscle fibers.
2002. Cell Calcium 32, 193-200.
26. ROSSI D. and SORRENTINO V. Molecular genetics
of ryanodine receptors / Ca2+ release channels. 2002. Cell Calcium
32, 307-319
27. BAGNATO P., BARONE V., ROSSI D. AND SORRENTINO
V. Binding of an Ankyrin-1 isoform to the C-terminus of Obscurin
identifies a molecular link between the sarcoplasmic reticulum and
myofibrils in striated muscles. 2003. J. Cell. Biology 160,245-253.
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