Giampiero Muccioli
C.V.

Articoli originali su riviste internazionali

Allia E., Tarabra E., Volante M., Cerrato M., Ghigo E., Muccioli G., Papotti M.Expression of cortistatin and MrgX2, a specific cortistatin receptor, in human neuroendocrine tissues and related tumours.J. Pathol. 207, 336-345; 2005.

Sibilia V., Muccioli G., Deghenghi R., Pagani F., De Luca V., Rapetti D., Locatelli V., Netti C. Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat.J. Neuroendocrinol. 18, 122-128; 2006.

Grottoli S., Gasco V., Broglio F., Balzelli R., Ragazzoni F., Gallenca F., Mainolfi A., Prodam F., Muccioli G., Ghigo E. Cortistatin-17 and somatostatin-14 display the same effects on growth hormone, prolactin, and insulin secretion in patients withacromegaly or prolactinoma.J. Clin. Endocrinol. Metab. 91, 595-599; 2006.

Granata R., Settanni F., Trovato L., Destefanis S., Gallo D., Martinetti M., Ghigo E., Muccioli G. Unacylated as well as acylated ghrelin promotes cell survivaland inhibits apoptosis in HIT-T15 pancreatic beta-cells. J. Endocrinol. Invest. 29, RC19-22; 2006.

Cassoni P., Allia E., Marrocco T., Ghè C., Ghigo E., Muccioli G., Papotti M. Ghrelin and cortistatin in lung cancer: expression of peptides and related receptors in human primary tumors and in vitro effect on the H345 smal cell carcinoma cell line. J. Endocrinol. Invest. 29, 781-790; 2006.

Granata R., Settanni F., Biancone L., Trovato L., Nano R., Bertuzzi F., Destefanis S., Annunziata M., Martinetti M., Catapano F., Ghè C., Isgaard J., Ghigo E., Papotti M., Muccioli G. Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta cells and human islets. Involvement of cAMP/PKA, ERK 1/2 and PI3K/AKT signalling. Endocrinology  148, 512-529;2007.

Benso A., Prodam F., Lucatello B., Gramaglia E., Riganti F., Schneider H., van der Lely A.J., Muccioli G., Ghigo E., Broglio F. d-Lys-GHRP6 does not modify the endocrine response to acylated ghrelin or hexarelin in humans. Neuropeptides 41, 45-49; 2007.

Filigheddu N., Gnocchi V.F., Coscia M., Cappelli M., Porporato P.E., Taulli R., Traini S., Baldanzi G., Chianale F., Cutrupi S., Arnoletti E., Ghè C., Fubini A., Surico N., Sinigaglia F., Ponzetto C., Muccioli G., Crepaldi T., Graziani A. Ghrelin and des-acyl ghrelin promote differentiation and fusion of C2C12 skeletal muscle cells. Mol. Biol. Cell. 18, 986-994; 2007.

Giordano R., Picu A., Bonelli L., Broglio F., Prodam F., Grottoli S.,  Muccioli G., Ghigo E., Arvat E. The activation of somatostatinergic receptors by either somatostatin-14 or cortistatin-17 often inhibits ACTH hypersecretion in patients with Cushing’s disease. Eur. J. Endocrinol. 157, 393-398; 2007.

Prodam F., Benso A., Gramaglia E., Lucatello B., Riganti F., van der Lely A.J., Deghenghi R., Muccioli G., Ghigo E., Broglio F. Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modufy the endocrine responses to acylated ghrelin or hexarelin in humans. Neuropeptides 42, 89-93; 2008.

Granata R., Settanni F., Gallo D., Trovato L., Biancone L., Cantaluppi V., Nano R., Annunziata M., Campiglia P., Arnoletti E., Ghè C., Volante M., Papotti M., Muccioli G., Ghigo E. Obestatin promotes survival of pancreatic cells and human islets and induces expression of genes involved in the regulation of cell mass and function. Diabetes 57, 967-979; 2008.

Johansson I., Destefanis S., Aberg N.D., Aberg M.A., Blomgren K., Zhu C., Ghè C., Granata R., Ghigo E., Muccioli G., Eriksson P., Isgaard J. Proliferative and protective effects of growth hormone secretagogues on adult rat hippocampal progenitor cells. Endocrinology  149, 2191-2199; 2008.

Broglio F., Prodam F., Riganti F., Gottero C., Destefanis S., Granata R., Muccioli G., Abribat T., van der Lely A.J., Ghigo E. The continous infusion of acylated ghrelin enhances growth hormone secretion and worsens glucose metabolism in humans. J. Endocrinol. Invest.  31, 788-794; 2008.

Granata R., Volante M., Settanni F., Gauna C., Ghè C., Annunziata M., Deidda B., Gesmundo I., Abribat T.,  van der Lely A.J., Muccioli G.,  Ghigo E. Unacylated gherlino and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats. J. Mol. Endocrinol.  45, 9-17; 2010.

Lear P.V., Iglesias M.J., Feijoo-Bandin S., Rodriguez-Penas D., Mosquera-Leal A., Garcia-Rua V., Gualillo O., Arnoletti E., Ghè C., Muccioli G., Dieguez C., Gonzalez-Juanatey J.R., Lago F. Des-acyl ghrelin has specific binding sites and different metabolic effects from ghrelin in cardiomyocytes. Endocrinology  151, 3286-3298; 2010.

Alloatti G., Arnoletti E., Bassino E., Penna C., Perrelli M.G., Ghè C., Muccioli G. Obestatin affords cardioprotection to the ischemic-reperfused isolated rat heart and inhibits apoptosis in cultures of similarly stressed cardiomyocytes. Am. J. Physiol. Heart Circ. Physiol.  299, H470-481; 2010. 

Monografie e rassegne su riviste internazionali

Ghigo E., Broglio F., Arvat E., Maccario M.,  Papotti M., Muccioli G.
Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor. Clin. Endocrinol.  62:1-17; 2005.

Broglio F., Prodam F., Me E., Riganti F., Lucatello B., Granata R., Benso A., Muccioli G., Ghigo E. Ghrelin: endocrine, metabolic and cardiovascular actions. J. Endocrinol. Invest. 28 (suppl. 5) 23-25; 2006.

Broglio F., Prodam F., Riganti F., Muccioli G., Ghigo E. Ghrelin: from somatotrope to new perspectives in the regulation of peripheral metabolic function. Front. Horm. Res. 35, 102-114; 2006.

Broglio F., Papotti M., Muccioli G., Ghigo E. Brain-gut communication: cortistatin, somatostatin and ghrelin. Trends Endocrinol. Metab. 18, 246-251; 2007.

Muccioli G., Baragli A., Granata R., Papotti M., Ghigo E. Heterogeneity of ghrelin/Growth Hormone Secretagogue receptors: Toward the understanding of the molecular identity of novel ghrelin/GHS receptors. Neuroendocrinology 86, 147-164; 2007.

Lanfranco F., Baldi M., Cassoni P., Bosco M., Ghè C., Muccioli G. Ghrelin and prostate cancer. Vitam. Horm. 77, 301-324; 2008.

Volante M., Rosas R., Allia E., Granata R., Baragli A., Muccioli G., Papotti M. Somatostatin, cortistatin and their receptors in tumours. Mol. Cell. Endocrinol. 286, 219-229; 2008.

Lorenzi T., Meli R., Marzioni D., Morroni M., Baragli A., Castellucci M., Gualillo O., Muccioli G. Ghrelin a metabolic signal affecting the reproductive system. Cytokine Growth Factor Rev. 20, 137-152; 2009.

Capitoli di Trattati

Muccioli G., Destefanis S., Broglio F., Gauna C. Farmacologia di fattori ipotalamici. In “Trattato di Farmacologia “ a cura di L. Annunziato e G. Di Renzo. Casa Editrice Idelson-Gnocchi, Napoli, Vol. II, Cap. 48, p. 916-924; 2010.

Muccioli G., Broglio F., Destefanis S.,  Gauna C. Ormoni dell’ipofisi posteriore. In “Trattato di Farmacologia”  a cura di L. Annunziato e G. Di Renzo. Casa Editrice  Idelson-Gnocchi, Napoli, Vol. II, Cap. 50, p. 949-958; 2010.