Maria Frosini
C.V.

Broccatelli F, Carosati E, Neri A, Frosini M, Oprea TI, Cruciani G. A Novel Approach for Predicting P-glycoprotein (ABCB1) Inhibition Using GRID Molecular Interaction Fields. J Med Chem, 2011, in press.

Anzini M, Chelini A, Mancini A, Cappelli A, Frosini M, Ricci L, Valoti M,Magistretti J, Castelli L, Giordani A, Makovec F, Vomero S. Synthesis and biological evaluation of amidine, guanidine, and thiourea derivatives of 2-amino(6-trifluoromethoxy)benzothiazole as neuroprotective agents potentially useful in brain diseases. J Med Chem. 2010 Jan 28;53(2):734-44.

Carosati E, Budriesi R, Ioan P, Cruciani G, Fusi F, Frosini M, Saponara S,Gasparrini F, Ciogli A, Villani C, Stephens PJ, Devlin FJ, Spinelli D, Chiarini A. Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker. J Med Chem. 2009 Nov 12;52(21):6637-48.

Ricci L, Valoti M, Sgaragli G, Frosini M. Protection by taurine of rat brain cortical slices against oxygen glucose deprivation- and reoxygenation-induced damage. Eur J Pharmacol. 2009 Oct 25;621(1-3):26-32.

Budriesi R, Cosimelli B, Ioan P, Ugenti MP, Carosati E, Frosini M, Fusi F, Spisani R, Saponara S, Cruciani G, Novellino E, Spinelli D, Chiarini A. L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives. J Med Chem. 2009 Apr 23;52(8):2352-62.

Martelli C, Alderighi D, Coronnello M, Dei S, Frosini M, Le Bozec B, Manetti D, Neri A, Romanelli MN, Salerno M, Scapecchi S, Mini E, Sgaragli G, Teodori E. N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent transporter-dependent multidrug resistance inhibitors. J Med Chem. 2009 Feb 12;52(3):807-17.

Carosati E, Budriesi R, Ioan P, Ugenti MP, Frosini M, Fusi F, Corda G, Cosimelli B, Spinelli D, Chiarini A, Cruciani G. Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening. J Med Chem. 2008 Sep 25;51(18):5552-65.

Ricci L, Valoti M, Sgaragli G, Frosini M. Neuroprotection afforded by GABA against oxygen-glucose deprivation-induced injury in rat cortical brain slices: an hormetic dose-response effect. American Journal of Pharmacology and Toxicology 2008 3(1): 157-164. Invited Paper.

Dragoni S, Materozzi G, Pessina F, Frosini M, Marco JL, Unzeta M, Sgaragli G, Valoti M. CYP-dependent metabolism of PF9601N, a new monoamine oxidase-B inhibitor, by C57BL/6 mouse and human liver microsomes. J Pharm Pharm Sci. 2007;10(4):473-85.

Frosini M. Changes in CSF composition during heat stress and fever in conscious rabbits. Prog Brain Res. 2007;162:449-57. Invited Review.

Ricci L, Valoti M, Sgaragli G, Frosini M. Neuroprotection afforded by diazepam against oxygen/glucose deprivation-induced injury in rat cortical brain slices. Eur J Pharmacol. 2007 Apr 30;561(1-3):80-4.

Carosati E, Cruciani G, Chiarini A, Budriesi R, Ioan P, Spisani R, Spinelli D, Cosimelli B, Fusi F, Frosini M, Matucci R, Gasparrini F, Ciogli A, Stephens PJ, Devlin FJ. Calcium channel antagonists discovered by a multidisciplinary approach. J Med Chem. 2006 Aug 24;49(17):5206-16.

Meini A, Garcia JB, Pessina GP, Aldinucci C, Frosini M, Palmi M. Role of intracellular Ca2+ and calmodulin/MAP kinase kinase/extracellular signal-regulated protein kinase signalling pathway in the mitogenic and antimitogenic effect of nitric oxide in glia- and neurone-derived cell lines. Eur J Neurosci. 2006 Apr;23(7):1690-700.

Frosini M, Ricci L, Saponara S, Palmi M, Valoti M, Sgaragli G. GABA-mediated effects of some taurine derivatives injected i.c.v. on rabbit rectal temperature and gross motor behavior. Amino Acids. 2006 May;30(3):233-42.

Ricci L, Frosini M, Gaggelli N, Valensin G, Machetti F, Sgaragli G, Valoti M. Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis. Biochem Pharmacol. 2006 May 14;71(10):1510-9.

Fusi F, Iozzi D, Sgaragli G, Frosini M. 3,5-di-t-butylcatechol (DTCAT) as an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC). Biochem Pharmacol. 2005 Feb 1;69(3):485-91.