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1)
Research
Grants Active as Principal Investigator
NIH
RO1 CA094804-02 (P.I.: K. Khalili) 03/04/02-12/31/06
Title: Human Neurotropic JC Virus and CNS Diseases$222,500 (Direct Cost
for entire project)
Co P.I.: A. Giordano, 10% effort
NIH R21
CA94802-01 (P.I.: A. Giordano) 7/1/02-6/30/04
National Cancer Institute $100,000
(Direct Cost) 20% effort
Title: Functional Interaction between HIV-1 products and cell cycle
proteins
NIH PO1NS36466 (Khalili, K., Program Director) 09/01/03-08/31/08
Program Project Title: Viral Model for Tumor Pathogenesis in Brain
A. Giordano, Project #2, 20% effort, $200,000 (Direct
Cost of Proj. #2)
Proj. #2 Title: Tumor Suppressor Rb Family/Rb2 in Medulloblastoma
NIH (P.I.: A.
Giordano) 4/1/04 – 3/31/09
Title: pRb2/p130: from the mechanisms to gene therapy
$1,250,000 (Total Direct Costs Requested) 40% effort
Source: Sbarro Institute for Cancer Research and Molecular Medicine
Date and cost of entire project: 3/1/02 - 3/1/05 $ 450,000 (additional
$120.000 starting 6/1/03)
NIH
Postdoctoral Fellowships
Valeria Masciullo, M.D., Ph.D. $42,000
Fellowships funded by the Italian government
Gaia Gallo,
M.D. $25,000
Chiara
Gabellina, M.D.
$25,000
Giuseppina D'Andrilli,
Ph.D. $20,000
Alessandro
Bovicelli, M.D. $25,000
Tiziana
Tonini, Ph.D. $22,000
Micaela
Montanari PhD $20,000
Chiara Mariano MD $25.000
2)
GRANTS:
Expired
Research Grants funded as Principal Investigator
Title: The
Adenovirus E1A Transforming region associate in vitro with two novel
cellular factors
Source: Milheim Foundation For Cancer Research
Date and cost of entire project: 6/1/93 - 6/30/94 $ 15,000 (Direct Cost)
Title:
Characterization and Identification of Novel Tumor Suppressor Genes.
Source: W. W. Smith Charitable Trust
Date and cost of entire project: 1/1/93 - 1/1/95 $ 184,000 (Direct Cost)
Title:
Molecular cloning of the Tumor Liberated Protein (TLP)
Source: Istituto
Farmacoterapico Italiano (IFI)
Date and cost of entire project: 2/1/96 -2/1/97 $ 64,000 (Direct Cost)
Title:
p130/Rb2 a Novel Target for the Ad5 E1A Oncoproteins.
Source: NIH RO1
Date and cost of entire project: 12/1/94 - 12/31/97 $ 447,000 (Direct
Cost)
Title: The
Role of pRb2 in Cell Proliferation.
Source: The Council for Tobacco Research
Date and cost of entire project: 1/1/95 - 1/1/98 $150,000 (Direct Cost)
Title: The
Role of pRb2 in Cell Proliferation.
Source: The Council for Tobacco Research
Date and cost of entire project: 1/1/98 - 1/1/99 $35,000 (Direct Cost)
Title:
Cancer and Cell Cycle
Source: Sbarro Institute for Cancer research and Molecular Medicine
Date and cost of entire project: 10/1/95 - 6/1/99 $ 600,000 (Direct Cost)
3)
PATENTS AWARDED:
Antonio Giordano,
”Tumor Suppressor Protein pRB2, related gene products, and DNA encoding
therefor” U.S. Patent Serial No. 5,457,049, issued October 10, 1995.
Antonio Giordano,
”Tumor Suppressor Protein pRB2, related gene products, and DNA encoding
therefor” U.S. Patent Serial No. 5,532,340, issued July 2, 1996.
Antonio Giordano,
“Human Cyclin-Dependent Kinase-like Proteins and Methods of Using the
Same,” U.S. Serial Number 5,674,748, issued on October 7, 1997.
Antonio Giordano
and A.
Baldi, “Human Retinoblastoma-Related (pRb2/p130) Genomic DNA and Methods
of Detecting Mutations Therein. US. Patent Application Serial No.
5,807,681, issued on Sep. 15, 1998.
Antonio Giordano
“Method
for the Diagnosis and Prognosis of Cancer.” US. Patent Application Serial
No. 08/840,506, issued on November 24, 1998.
Antonio Giordano,
“Human Cyclin-Dependent Kinase-like Proteins and Methods of Using the
Same,” U.S. Serial Number 6,162,612, issued on December 19, 2000.
Antonio Giordano "Determination
of Cyclin-Dependent Kinase Inhibitor p27 levels as a prognostic factor in
cancer patients." U.S. Patent Application Serial No. 6,180,133 issued on
January 30, 2001.
Antonio Giordano "pRb2/p130
Peptide Inhibitors of cdk2 Kinase activity" U.S. Patent Application Serial
No. 6,297,357 issued on October 2 2001.
Antonio Giordano
and Pier Paolo Claudio " Methods of inhibiting smooth muscle cell
proliferation and preventing restenosis with a vector expressing RB2/p130
" U.S. Patent Application Serial No. 6,596,698 issued on July 22 2003.
Pending:
Five
additional patents have been filed and are under examination. |