Alfonso POMPELLA, MD PhD (Aversa, 1956)

Doctoral Degree: Medicine and Surgery - General Pathology (Pathogenesis of Ceroid-lipofuscinosis; 1980, University of Siena)

Residency training: Clinical Neurology

Dottorato di Ricerca: Experimental & Molecular Pathology (Glutathione depleting agents and cell injury; 1987, University of Turin)

CURRICULUM VITAE ET STUDIORUM:

1974 : High School Degree (Classical Studies) in Aversa (Caserta);

1975-1980 : Student of Medicine, Universities of Naples and Siena;

1979 : Involved in a research project at the Dept. of Chemical Pathology, Whittington Hospital, London, U.K. (Chair: Prof. T.L. Dormandy);

1980 : Degree in Medicine and Surgery cum laude at the University of Siena, with a Thesis in General Pathology titled: ''On the pathogenesis of Neuronal Ceroid-Lipofuscinosis" (Supervisor: Prof. Mario Comporti);

1982 : Admitted as Intern at the Institute of General Pathology, University of Siena (Chair: Prof. Mario Comporti);

1984-1987 : Ph.D. Course ('Dottorato di Ricerca') in Experimental and molecular Pathology at the University of Turin, Italy (Supervisor: Prof. M.U. Dianzani);

1988 : Ph.D. Thesis, titled: "Pathogenic mechanisms of the hepatic and extrahepatic injury induced by bromobenzene"

July 1990 : Following a national selection, is appointed Assistant Researcher in General Pathology, at the Faculty of Medicine and Surgery of the University of Siena;

1990 : Involved in a joint research project on glutathione-conjugation of lipid peroxidation products, at the Department of Biochemistry, University College and Middlesex School of Medicine, London, U.K. (Chair: Prof. Brian Ketterer);

1992 : Following a national selection, is appointed Associate Professor of General Pathology at the Faculty of Medicine and Surgery of the University of Siena;

1993 : Involved in a joint research project on histochemistry of lipid peroxidation products, at the Laboratory of Histology and Cell Biology, University of Amsterdam, The Netherlands (Chair: J.C.F. Van Noorden);

1994-97 : Responsible of a Research Unit included in the National Project "Biology and Pathology of the Cell Cycle" (Funds provided by the Italian Ministry for University and Scientific Research);

1996, 1999 : Appointed President of the University Course for Biomedical Technicians, University of Siena;

1999 : Elected as a Member in the European Committee of the Society for Free Radical Research;

March 2000 : Visiting Professor at the Centre du Médicament, Faculté de Pharmacie, Université Henri Poincaré Nancy, France;

Nov. 2000 : Following a selection at the University of Turin, is appointed Full Professor of General Pathology at the Faculty of Medicine and Surgery, University of Pisa, Italy.

RESEARCH AND PROFESSIONAL EXPERIENCE:

Prof. A. Pompella is author of over 65 papers, published in international peer-reviewed scientific Journals, and of approx. 90 presentations at national and international congresses. Has served as Reviewer for Journals as Biochemical Pharmacology, Biochimica et Biophysica Acta, Free Radical Biology and Medicine, Pharmacology, FASEB Journal, as well as for the Wellcome Foundation. Member of the Società Italiana di Patologia, the Society for Free Radical Research, the Union Internationale Contre le Cancer, and the Society for Histochemistry.

Research activity of Prof. Pompella is dedicated to molecular mechanisms, histochemistry and pathophysiologic effects of oxidant stress and lipid peroxidation. His more recent studies were concerned with the identification in vivo of products of lipid peroxidation, the pro-oxidant effects of membrane-bound gamma-glutamyl transpeptidase activity, the role of the cell redox balance in modulation of cell proliferation and apoptosis in tumor cells.