Professore Ordinario -
Dipartimento di Anatomia, Farmacologia e Medicina Legale
Università degli Studi di Torino

Curriculum vitae italiano
Lauree e Diplomi: 1956, Laurea in Medicina; 1962, Special. Medicina Interna (Univ. Bari).
1965, PhD Patol. Chim. (Univ. Londra).
Posti occupati:1965-93, Ricercatore nel Medical Research Council (MRC), UK;
1977-93, Capo Sez. Farmacol. Bioch. e 1987-93,  Vicediret. Toxicol.Unit, MRC, UK;
1993- Profess. Ord. Tossicologia, Facolta' di Medicina, Univ.Torino.
"Fellowship" e "Awards": 1989, Fellowship Institute  Biology;
1993,  Barnes Award Lecture/ Brit. Toxicol. Soc.;
1993, Accademia Medicina, Torino (socio onorario).
Attivita' Editoriale: Ho curato i seguenti volumi: Heme and Hemoproteins, Springer Verlag, 1978;
Microsomes and Drug Oxidation , Taylor and Francis, London, 1985;
Selectivity and Molecular Mechanisms of Toxicity, Macmillan, London, 1987;
Molecular and Cellular Mechanisms of Toxicity,CRC Press, 1995.
Sono o sono stato membro dell'Editorial Board di 7 riviste internazionali e dell'Editorial Advisory Board di altre 3.
Ho insegnato come"Visiting Professor" a Kyoto, Kingston (Ontario), Siena,
Padova, Brisbane e Citta' del Messico ed ho trascorso periodi di ricerca al
Karolinska, Universita' di Parigi e nel Vermont, USA.

Curriculum vitae english
Degrees and Diplomas: 1956, Degrees in Medicine and 1962 Internal Medicine,
Bari, Italy;
1965, PhD in Chemical Pathology, London, UK;
Positions held: 1962-63, Research Associate, Univ. Minnesota, USA;
1965-93, Scientific Staff in the British Medical Research Council (MRC);
1977-93, Head of Biochemical Pharmacology Section and 1987-93, Deputy Director, Toxicology
Unit, MRC;
1993- Professor of Toxicology, Turin University.  "Fellowship" e "Awards": 1989, Fellowship Instit. Biology;
1993,  Barnes Award Lecture/Brit.Toxicol. Soc.;
1993, Accad. Medicina, Turin (Honorary member). Editorial Activity: Editor of:Heme and Hemoproteins, Springer Verlag, 1978; Microsomes and Drug Oxidation , Taylor & Francis, London, 1985;
Selectivity and Molecular Mechanisms of Toxicity, Macmillan, London, 1987;
Molecular and Cellular Mechanisms of Toxicity,CRC Press, 1995.
Member of the Editorial Board of 7 internat journals and of the adv.board of other 3.
Visiting Professorships held at Kyoto, Kingston (Ontario), Siena, Padova, Brisbane and Mexico City with periods of research activity at the Karolinska Inst., Paris University and in Vermont, USA.

Pubblicazioni dal 1998
Lavori in Riviste scientifiche col "peer review system"

STONARD, M.D., POLI, G. and DE MATTEIS, F. Stimulation of liver heme oxygenase in hexachlorobenzene-induced hepatic porphyria. Arch. Toxicol. 72  355-361  (1998)

VALOTI, M., FROSINI, M., PALMI M., DE MATTEIS, F. and SGARAGLI, G.  N
-Dealkylation of Chlorimipramine and Chlorpromazine by rat liver microsomal cytochrome P450 isoenzymes. J Pharm. Pharmacol.  50 1005-1011  (1998).

DE MATTEIS, F., WHITE,  I. N.H. and  SMITH, L.L. Species differences in the metabolic activation   of Tamoxifen into genotoxic derivatives: risk assessment in women.  Eur. J. Drug Metab. Pharmacok., 23  425-428 (1998).

SCHWARZER, E., DE MATTEIS F., GIRIBALDI G., ULLIERS D., VALENTE E. and ARESE P.
Hemozoin stability and dormant induction of heme oxygenase in hemozoin-fed human monocytes
Mol Biochem Parasitology  100 61-72 (1999)

ALBORES A., CEBRIAN, M.E., DEKANT, W., DE MATTEIS F. et al. Structural improvement of higher education in environmental toxicology in Latin Amarica and Europe. Toxicol Lett  111  203-211 (2000).

ZACCARO C., SWEITZER S., PIPINO S., GORMAN N., SINCLAIR PR., SINCLAIR JF.,
NEBERT D W. and  DE MATTEIS F. Role of Cytochrome P450 1A2 in biliruibin degradation. Stidies in CYP1a2 (-/-) mutant mice. Biochem Pharmacol (2001), in press.

CANTONI, L.,  DI NICOLANTONIO F., BARELLI D., RIZZARDINI M and DE MATTEIS F.
Modulation of Cerebellar and Hepatic Nitric Oxide Synthase by Exogenous Arginine and Endotoxin.
NITRIC OXIDE Biol Chem  5 ŠŠ (2001), in press.

CONTRIBUTI A RIUNIONI  SCIENTIFICHE

RAZVI, N., GIBBS, A.H., DAVIES, A.M, MANNO,M., ZACCARO C., DE MATTEIS, F.
and  WHITE, I.N.H. Clastogenic action of certain chlorofluorohydrocarbons in human MCL-5 cells. Human & Exp. Toxicol., 17  510   (1998).

GIBBS, A.H., RAZVI, N., DAVIES, A.M., MANNO, M., ZACCARO, C., DE MATTEIS, F. and WHITE, I.N.H. Activation by human CYP Isoenzymes of chlorofluorohydrocarbons that results in clastogenicity and protein
binding. Proceed. 12th Intern. Symp. Micros. Drug Oxid. Montpellier (1988) abstract no.86.

 ZACCARO, C., DI NICOLANTONIO, F., SWEITZER, S., GORMAN, N., SINCLAIR, P.,
SINCLAIR, J. and DE MATTEIS, F. Role of CYP 1A1 and 1A2 in Bilirubin Oxidation. Proceed. 12th Intern. Symp. Micros. Drug Oxid. Montpellier (1988) abstract no. 233.

LONGO, V., MARINI, S., DE MATTEIS, F.and GERVASI, P.G. Bioactivation of solvents in the olfactory tissue. Proceedings. Intern. Conference on in vitro cytotoxicity mechanisms, page 59. Rome (1999).

BORTOLATO, S., OROPEZA, L.F., PAHLER, A., ALBORES A., DEKANT, W., WHITE
I.N.H., DE MATTEIS, F. and MANNO, M. Detection of trifluoroacetylated proteins in liver, kidney and plasma of rats treated with halothane. Proceedings. Intern. Conference on in vitro cytotoxicity mechanisms, page
61. Rome (1999).

LONGO V., MARINI S., DE MATTEIS F. and GERVASI PG. Inactivation  and Induction of the nasal Cytochromes P450 of Mammals. Proceed. 13th Intern. Symp. Micros. Drug Oxid,  Stresa(2000) abstract no.211.

Articoli di rassegna

DE MATTEIS, F. Porphyria Cutanea Tarda of the Toxic and Sporadic Varieties. Clin Derm.  16  265-275  (1998).