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The Prigogine Lectures. Siena 9 July 2009 - 4 pm
Aula Magna Rettorato


Winner of the Nobel Prize in Chemistry 1977

The following is taken from a translation of Prigogine's French language autobiography:

I was born in Moscow, on the 25th of January, 1917 - a few months before the revolution. My family had a difficult relationship with the new regime, and so we left Russia as early as 1921. For some years (until 1929), we lived as migrants in Germany , before we stayed for good in Belgium. It was at Brussels that I attended secondary school and university. I acquired Belgian nationality in 1949.

My father, Roman Prigogine, who died in 1974, was a chemical engineer from the Moscow Polytechnic. My brother Alexander, who was born four years before me, followed, as I did myself, the curriculum of chemistry at the Université Libre de Bruxelles. I remember how much I hesitated before choosing this direction; as I left the classical (Greco-Latin) section of Ixelles Athenaeum, my interest was more focused on history and archaeology, not to mention music, especially piano.
According to my mother, I was able to read musical scores before I read printed words. And, today, my favourite pastime is still piano playing.
In 1941, I was conferred my first doctoral degree. Very soon, two of my teachers were to exert an enduring influence on the orientation of my future work.

I would first mention Théophile De Donder (1873-1957). After 1918, he was promoted to Professor at the Department of Applied Science, and began writing a course on theoretical thermodynamics for engineers. It is with this very circumstance that we have to associate the birth of the Brussels thermodynamics school.
In order to understand fully the originality of De Donder's approach, I have to recall that since the fundamental work by Clausius, the second principle of thermodynamics has been formulated as an inequality: "uncompensated heat" is positive - or, in more recent terms, entropy production is positive. This inequality refers, of course, to phenomena that are irreversible, as are any natural processes.
In those times, these latter were poorly understood. They appeared to engineers and physico-chemists as "parasitic" phenomena, which could only hinder something: here the productivity of a process, there the regular growth of a crystal, without presenting any intrinsic interest. So, the usual approach was to limit the study of thermodynamics to the understanding of equilibrium laws, for which entropy production is zero.
This could only make thermodynamics a "thermostatics". In this context, the great merit of De Donder was that he extracted the entropy production out of this "sfumato" when related it in a precise way to the pace of a chemical reaction, through the use of a new function that he was to call "affinity".
It is difficult today to give an account of the hostility that such an approach was to meet. Fortunately, some eminent scientists derogated this negative attitude. I received much support from people such as Edmond Bauer, the successor to Jean Perrin at Paris, and Hendrik Kramers in Leyden.
De Donder, of course, had precursors, especially in the French thermodynamics school of Pierre Duhem . But in the study of chemical thermodynamics, De Donder went further, and he gave a new formulation of the second principle, based on such concepts as affinity and degree of evolution of a reaction, considered as a chemical variable.
Given my interest in the concept of time, it was only natural that my attention was focused on the second principle, as I felt from the start that it would introduce a new, unexpected element into the description of physical world evolution. A huge part of my scientific career would then be devoted to the elucidation of macroscopic as well as microscopic aspects of the second principle, in order to extend its validity to new situations, and to the other fundamental approaches of theoretical physics, such as classical and quantum dynamics.
I would also like to stress the influence on my scientific development that was exerted by the second of my teachers, Jean Timmermans (1882-1971). He was more an experimentalist, specially interested in the applications of classical thermodynamics to liquid solutions, and in general to complex systems, in accordance with the approach of the great Dutch thermodynamics school of van der Waals and Roozeboom.
In this way, I was confronted with the precise application of thermodynamical methods, and I could understand their usefulness. In the following years, I devoted much time to the theoretical approach of such problems, which called for the use of thermodynamical methods; I mean the solutions theory, the theory of corresponding states and of isotopic effects in the condensed phase. A collective research with V. Mathot, A. Bellemans and N. Trappeniers has led to the prediction of new effects such as the isotopic demixtion of helium He3+ He4, which matched in a perfect way the results of later research.
Among all those perspectives opened by thermodynamcis, the one which was to keep my interest was the study of irreversible phenomena, which made so manifest the "arrow of time". From the very start, I always attributed to these processes a constructive role, in opposition to the standard approach, which only saw in these phenomena degradation and loss of useful work. The fact is that it appeared to me that living things provided us with striking examples of systems which were highly organized and where irreversible phenomena played an essential role.
Such intellectual connections, although rather vague at the beginning, contributed to the elaboration, in 1945, of the theorem of minimum entropy production, applicable to non-equilibrium stationary states. This theorem gives a clear explanation of the analogy which related the stability of equilibrium thermodynamical states and the stability of biological systems, such as that expressed in the concept of "homeostasy" proposed by Claude Bernard. This is why, in collaboration with J.M. Wiame, I applied this theorem to the discussion of some important problems in theoretical biology, namely to the energetics of embryological evolution. As we better know today, in this domain the theorem can at best give an explanation of some "late" phenomena, but it is remarkable that it continues to interest numerous experimentalists. From the very beginning, I knew that the minimum entropy production was valid only for the linear branch of irreversible phenomena, the one to which the famous reciprocity relations of Onsager are applicable. And, thus, the question was: What about the stationary states far from equilibrium, for which Onsager relations are not valid, but which are still in the scope of macroscopic description? Linear relations are very good approximations for the study of transport phenomena (thermical conductivity, thermodiffusion, etc.), but are generally not valid for the conditions of chemical kinetics. Indeed, chemical equilibrium is ensured through the compensation of two antagonistic processes, while in chemical kinetics - far from equilibrium, out of the linear branch - one is usually confronted with the opposite situation, where one of the processes is negligible.
Notwithstanding this local character, the linear thermodynamics of irreversible processes had already led to numerous applications, as shown by people such as J. Meixner, S.R. de Groot and P. Mazur, and, in the area of biology, A. Katchalsky.
It was for me a supplementary incentive when I had to meet more general situations.
Those problems had confronted us for more than twenty years, between 1947 and 1967, until we finally reached the notion of "dissipative structure".
During this phase of my work, the original and enthusiastic mind of my colleague Paul Glansdorff played a major role.
Our collaboration was to give birth to a general evolution criterion which is of use far from equilibrium in the non-linear branch, out of the validity domain of the minimum entropy production theorem. Stability criteria that resulted were to lead to the discovery of critical states, with branch shifting and possible appearance of new structures. This quite unexpected manifestation of "disorder-order" processes, far from equilibrium, but conforming to the second law of thermodynamics, was to change in depth its traditional interpretation. In addition to classical equilibrium structures, we now face dissipative coherent structures, for sufficient far-from- equilibrium conditions.
In a first, tentative step, we thought mostly of hydrodynamical applications, using our results as tools for numerical computation. Here the help of R. Schechter from the University of Texas at Austin was highly valuable. Those questions remain wide open, but our centre of interest has shifted towards chemical dissipative systems, which are more easy to study than convective processes.
All the same, once we formulated the concept of dissipative structure, a new path was open to research and, from this time, our work showed striking acceleration.
This was due to the presence of a happy meeting of circumstances; mostly to the presence in our team of a new generation of clever young scientists. I cannot mention here all those people, but I wish to stress the important role played by two of them, R. Lefever and G. Nicolis. It was with them that we were in a position to build up a new kinetical model, which would prove at the same time to be quite simple and very instructive - the? Brusselator?, as J. Tyson would call it later - and which would manifest the amazing variety of structures generated through diffusion- reaction processes.
It was only quite a while later that I recalled the comments by A. Turing on those questions of stability, as, perhaps too concerned about linear thermodynamics, I was then not receptive enough.
Let us go back to the circumstances that favoured the rapid development of the study of dissipative structures. The attention of scientists was attracted to coherent non-equilibrium structures after the discovery of experimental oscillating chemical reactions such as the Belusov-Zhabotinsky reaction; the explanation of its mechanism by Noyes and his co-workers; the study of oscillating reactions in biochemistry (for example the glycolytic cycle, studied by B. Chance and B. Hess) and eventually the important research led by M. Eigen. Therefore, since 1967, we have been confronted with a huge number of papers on this topic, in sharp contrast with the total absence of interest which prevailed during previous times.
But the introduction of the concept of dissipative structure was also to have other unexpected consequences. It was evident from start that the structures were evolving out of fluctuations. They appeared in fact as giant fluctuations, stabilized through matter and energy exchanges with the outer world. Since the formulation of the minimum entropy production theorem, the study of non-equilibrium fluctuation had attracted all my attention. It was thus only natural that I resumed this work in order to propose an extension of the case of far-from-equilibrium chemical reactions.
This subject I proposed to G. Nicolis and A. Babloyantz. We expected to find for stationary states a Poisson distribution similar to the one predicted for equilibrium fluctuations by the celebrated Einstein relations. Nicolis and Babloyantz developed a detailed analysis of linear chemical reactions and were able to confirm this prediction. They added some qualitative remarks which suggested the validity of such results for any chemical reaction.
Considering again the computations for the example of a non-linear biomolecular reaction I noticed that this extension was not valid. A further analysis, where G. Nicolis played a key role, showed that an unexpected phenomenon appeared while one considered the fluctuation problem in nonlinear systems far from equilibrium: the distribution law of fluctuations depends on their scale, and only "small fluctuations" follow the law proposed by Einstein. After a prudent reception, this result is now widely accepted, and the theory of non-equilibrium fluctuations is fully developing now, so as to allow us to expect important results in the following years. What is already clear today is that a domain such as chemical kinetics, which was considered conceptually closed, must be thoroughly rethought, and that a brand-new discipline, dealing with non-equilibrium phase transitions, is now appearing.
Progress in irreversible phenomena theory leads us also to reconsideration of their insertion into classical and quantum dynamics. Let us take a new look at the statistical mechanics of some years ago. From the very beginning of my research, I had had occasion to use conventional methods of statistical mechanics for equilibrium situations. Such methods are very useful for the study of thermodynamical properties of polymer solutions or isotopes. Here we deal mostly with simple computational problems, as the conceptual tools of equilibrium statistical mechanics have been well established since the work of Gibbs and Einstein. My interest in non-equilibrium would by necessity lead me to the problem of the foundations of statistical mechanics, and especially to the microscopic interpretation of irreversibility.
Since the time of my first graduation in science, I was an enthusiastic reader of Boltzmann, whose dynamical vision of physical becoming was for me a model of intuition and penetration. Nonetheless, I could not but notice some unsatisfying aspects. It was clear that Boltzmann introduced hypotheses foreign to dynamics; under such assumptions, to talk about a dynamical justification of thermodynamics seemed to me an excessive conclusion, to say the least. In my opinion, the identification of entropy with molecular disorder could contain only one part of the truth if, as I persisted in thinking, irreversible processes were endowed with this constructive role I never cease to attribute to them. For another part, the applications of Boltzmann's methods were restricted to diluted gases, while I was most interested in condensed systems.
At the end of the forties, great interest was aroused in the generalization of kinetic theory to dense media. After the pioneering work by Yvon, publications of Kirkwodd, Born and Green, and of Bogoliubov attracted a lot of attention to this problem, which was to lead to the birth of non-equilibrium statistical mechanics. As I could not remain alien to this movement, I proposed to G. Klein, a disciple of Fürth who came to work with me, to try the application of Born and Green's method to a concrete, simple example, in which the equilibrium approach did not lead to an exact solution. This was our first tentative step in non-equilibrium statistical mechanics. It was eventually a failure, with the conclusion that Born and Green's formalism did not lead to a satisfying extension of Boltzmann's method to dense systems.
But this failure was not a total one, as it led me, during a later work, to a first question: Was it possible to develop an "exact" dynamical theory of irreversible phenomena? Everybody knows that according to the classical point of view, irreversibility results from supplementary approximations to fundamental laws of elementary phenomena, which are strictly reversible. These supplementary approximations allowed Boltzmann to shift from a dynamical, reversible description to a probabilistic one, in order to establish his celebrated H theorem.
We still encountered this negative attitude of "passivity" imputed to irreversible phenomena, an attitude that I could not share. If - as I was prepared to think - irreversible phenomena actually play an active, constructive role, their study could not be reduced to a description in terms of supplementary approximations.
Moreover, my opinion was that in a good theory a viscosity coefficient would present as much physical meaning as a specific heat, and the mean life duration of a particle as much as its mass.
I felt confirmed in this attitude by the remarkable publications of Chandrasekhar and vo Neumann, which were also issued during the forties. That was why, still with the help of G. Klein, I decided to take a fresh look at an example already studied by Schrödinger, related to the description of a system of harmonic oscillators.
We were surprised to see that, for all such a simple model allowed us to conclude, this class of systems tend to equilibrium. But how to generalize this result to non- linear dynamical systems?
Here the truly historic performance of Léon van Hove opened for us the way (1955).
Some of his works had a lasting effect on the whole development of statistical physics; I mean not only his study of the deduction of a "master equation" for anharmonic systems, but also his fundamental contribution on phase transitions, which was to lead to the branch of statistical mechanics that deals with so-called "exact" results.
This first study by van Hove was restricted to weakly coupled anharmonic systems.
But, anyway, the path was open, and with some of my colleagues and collaborators, mainly R. Balescu, R. Brout, F. Hénin and P. Résibois, we achieved a formulation of non-equilibrium statistical mechanics from a purely dynamical point of view, without any probabilistic assumption. The method we used is summed up in my 1962 book. It leads to a "dynamics of correlations", as the relation between interaction and correlation constitutes the essential component of the description. Since then, these methods have led to numerous applications.
This concluded the first step of my research in non-equilibrium statistical mechanics.
The second is characterized by a very strong analogy with the approach of irreversible phenomena which led us from linear thermodynamics to non-linear thermodynamics. In this tentative step also, I was prompted by a feeling of dissatisfaction, as the relation with thermodynamics was not established by our work in statistical mechanics, nor by any other method. The theorem of Boltzmann was still as isolated as ever, and the question of the nature of dynamics systems to which thermodynamics applies was still without answer.
The problem was by far more wide and more complex than the rather technical considerations that we had reached. It touched the very nature of dynamical systems, and the limits of Hamiltonian description. I would never have dared approach such a subject if I had not been stimulated by discussions with some highly competent friends such as the late Léon Rosenfeld from Copenhagen , or G. Wentzel from Chicago . Rosenfeld did more than give me advice; he was directly involved in the progressive elaboration of the concepts we had to explore if we were to build a new interpretation of irreversibility. More than any other stage of my scientific career, this one was the result of a collective effort. I could not possibly have succeeded had it not been for the help of my colleagues M. de Haan, Cl. George, A. Grecos, F. Henin, F. Mayné, W. Schieve and M. Theodosopulu. If irreversibility does not result from supplementary approximations, it can only be formulated in a theory of transformations which expresses in "explicit" terms what the usual formulation of dynamics does "hide". In this perspective, the kinetic equation of Boltzmann corresponds to a formulation of dynamics in a new representation.
In conclusion: dynamics and thermodynamics become two complementary descriptions of nature, bound by a new theory of non-unitary transformation. I came so to my present concerns; and, thus, it is time to end this intellectual autobiography. As we started from specific problems, such as the thermodynamic signification of non-equilibrium stationary states, or of transport phenomena in dense systems, we have been faced, almost against our will, with problems of great generality and complexity, which call for reconsideration of the relation of physico-chemical structures to biological ones, while they express the limits of Hamiltonian description in physics. Indeed, all these problems have a common element: time. The research conducted with my friend R. Herman on the theory of car traffic gave me confirmation of the supposition that even human behaviour, with all its complexity, would eventually be susceptible of a mathematical formulation.
In this way the dichotomy of the "two cultures" could and should be removed.
There would correspond to the breakthrough of biologists and anthropologists towards the molecular description or the "elementary structures", if we are to use the formulation by Lévi-Strauss, a complementary move by the physico-chemist towards complexity. Time and complexity are concepts that present intrinsic mutual relations.
During his inaugural lecture, De Donder spoke in these terms: "Mathematical physics represents the purest image that the view of nature may generate in the human mind; this image presents all the character of the product of art; it begets some unity, it is true and has the quality of sublimity; this image is to physical nature what music is to the thousand noises of which the air is full..."
Filtrate music out of noise; the unity of the spiritual history of humanity, as was stressed by M. Eliade, is a recent discovery that has still to be assimilated. The search for what is meaningful and true by opposition to noise is a tentative step that appears to be intrinsically related to the coming into consciousness of man facing a nature of which he is a part and which it leaves.
The work of a theoretician is related in a direct way to his whole life. It takes, I believe, some amount of internal peace to find a path among all successive bifurcations. This peace I owe to my wife, Marina. I know the frailty of the present, but today, considering the future, I feel myself to be a happy man.