AP-1 Network Project

Curriculum Vitae

Personal Data

Date of birth: 26/01/1974
Nationality: Danish
Address: 14 rue Burdeau (n°23), 69001 Lyon, France
Tel: +33 6 50 25 05 83

Professional experience
2005-now From November, PhD-student in Marc Castellazzi’s team "Cellular and Viral Oncogenesis", INSERM Unit 758 of Human Virology.
2005 High school Biology teacher.

Education
2004 Course in Applied Bioinformatics, KVL, Copenhagen.
2003 Master of Science, University of Aarhus in Denmark, Institute of Biology. M. Sc. thesis in Retrovirology.
2000 Subsidiary course in French at the University of Aarhus.

Distinctions
2002-2003 Winner of a competitive one-year scholarship from the Danish Cancer Society.

Language
Danish (mother tongue), English and French fluent;

AP-1 Network Project

Reserch project

“AP1-mediated angiogenic response of human endothelial cells: effect of pathological products from viral origin”

Angiogenic responses of human endothelial cells to different physiological and pathogenic factors will be studied in vitro. Among the angiogenesis related phenotypes are proliferation, tubule formation from spheroids, and orientated cell migration. Of primary interest are the factors of the VEGF family and viral proteins such as Tat from HIV-1 and v-MIP and v-GPCR from HHV-8. The aim is to determine how these factors interfere with normal angiogenic regulation that may be mediated at least partly by transcription factors of the AP1 family, mainly the Jun:Jun, Jun:Fos, and Jun:ATF2/3 dimer combinations. Experiments are on-going to determine the effect of viral proteins on normal AP1 function. Production and use of lentiviral vectors in a P3 safety lab as well as recovering and cultivation of human primary endothelial cells (HUVEC) are pivotal techniques in this project. Part of this project is developped in close collaboration with the coordinator of the network, Prof Salvatore Oliviero, Siena.